Small molecule-induced DNA hydrogel with encapsulation and release properties

Hydrogel functionalization with DNA aptamers for sustained PDGF-BB release.

We demonstrate that hydrogel functionalization with DNA aptamers can be applied for developing a novel sustained-release system.

Encapsulation of Food Components and Bioactive Ingredients and Targeted Release

The potential utilization of encapsulation techniques in food, pharmaceutical and agricultural products preparation, presents a new alternative for complementary technologies such as targeting delivery vehicles and carriers for active food ingredients. Encapsulation could be accomplished by different techniques like: simple or complex coacervation, emulsification technique, phase separation, sp...

Single-molecule protein encapsulation in a rigid DNA cage.

Microfluidic Production of Alginate Hydrogel Particles for Antibody Encapsulation and Release.

Owing to their biocompatibility and reduced side effects, natural polymers represent an attractive choice for producing drug delivery systems. Despite few successful examples, however, the production of monodisperse biopolymer-based particles is often hindered by high viscosity of polymer fluids. In this work, we present a microfluidic approach for production of alginate-based particles carryin...

Active drug encapsulation and release kinetics from hydrogel-in-liposome nanoparticles.

Herein, we demonstrate for the first time the use of hydrogel-in-liposome nanoparticles (lipogels) as a promising drug delivery vehicle for the active encapsulation of the anticancer drug 17-DMAPG, a geldanamycin (GA) derivative. This model drug was chosen due to its improved aqueous solubility (4.6 mg/ml) compared to the parent GA (<0.01 mg/ml), and presence of a tertiary amine which readily p...